Edward Clarence Shepherd was born 24 July 1835 at Shepherdstown, West Virginia. He matriculated at the Virginia Military Institute on 4 August 1851 and graduated 4 July 1855, standing 8th of 16. After completing his education he became a teacher.
During the Civil War Shepherd enlisted 22 October 1861 at Centreville, Virginia as a Private, Company B, 2nd Virginia Infantry Regiment. He married Amelia Adelaid Shock of Baltimore, Maryland on 17 August 1870 and they had four children--Anna Isabelle (b. 1871 d. 1877), Edward Clarence, Jr. (b. 1876), Clinton Webb (b. 1880), and George Randolph (b. 1883 d. 1903). He continued his career as an educator and was Professor of Math, Frederick College (Maryland). Shepherd died 19 August 1907 at Frederick, Maryland.